کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8275114 1535103 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of B-cell depletion in the Theiler's model of multiple sclerosis
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
The effect of B-cell depletion in the Theiler's model of multiple sclerosis
چکیده انگلیسی
5D2-induced BCD was confirmed by demonstration of nearly absent CD19+ cells in the blood and lymphoid tissue. Systemic and CNS antibody responses were suppressed during 5D2 treatment. Higher viral loads were detected in 5D2-treated mice than in controls, and the viral levels correlated negatively with IgG production in the brain. Overall, 5D2 caused worsening of the early encephalitis and faster progression of disability, as well as exacerbation of the pathology of TMEV-IDD at the end stage of the disease. These data indicate that BCD in humans might worsen CNS viral infections and might not improve disability accrual in MS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Neurological Sciences - Volume 359, Issues 1–2, 15 December 2015, Pages 40-47
نویسندگان
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