Anti-dyskinetic effect of the neuronal nitric oxide synthase inhibitor is linked to decrease of FosB/DeltaFosB expression

► 6-OHDA-lesioned rat develops AIMs after receiving chronic l-DOPA treatment. ► FosB/ΔFosB expression increases in the dopamine-depleted striatum induced by l-DOPA. ► Inhibitor of nNOS reduced AIMs simultaneously to FosB/ΔFosB overexpression in the lesioned striatum.