Effects of lifestyle modifications on cognitive impairments in a mouse model of hypercholesterolemia

► Physical exercise and probucol decreased plasma cholesterol levels in LDLr−/− mice. ► Physical exercise mitigates the spatial memory deficits of LDLr−/− mice. ► Probucol did not mitigate the spatial memory deficits of LDLr−/− mice. ► Exposure to EE did not mitigate the spatial memory deficits of adult LDLr−/− mice. ► Exposure to EE induced persistent anxyolitic-like effects in LDLr−/− mice.