Clomipramine reverses hypoalgesia/hypoesthesia and improved depressive-like behaviors induced by inescapable shock in rats

► Learned helpless rats exhibited significant behavioral deficits and hypoalgesia/hypoesthesia. ► Clomipramine can attenuate the behavioral deficits of learned helpless rats. ► Clomipramine can reverse mechanical but not thermal hypoalgesia/hypoesthesia.