کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6283257 | 1615155 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Real-time magnetic resonance imaging visualization and quantitative assessment of diffusion in the cerebral extracellular space of C6 glioma-bearing rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Interstitial drug delivery is a promising technique for glioma treatment; however, suboptimal methodologies limit the ability to document the delivery of therapeutic agents. The present study employed magnetic resonance imaging for real-time visualization and quantitative assessment of drug diffusion in gliomas. Using gadolium-diethylenetriaminepentaacetic acid (Gd-DTPA) as a tracer, we considered diffusion in the agarose gel phantom as a reference and compared the diffusion and distribution patterns between the control group and C6 glioma-bearing rats after direct cerebral infusion. Our findings confirmed that Gd-DTPA diffusion was severely impaired in gliomas and presented in an anisotropic pattern in the caudate nucleus. The proposed method provides a new approach for the real-time monitoring of interstitial drug delivery and quantitative assessment of biophysical structural variations in diseased tissue.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 543, 24 May 2013, Pages 84-89
Journal: Neuroscience Letters - Volume 543, 24 May 2013, Pages 84-89
نویسندگان
Kai Li, Hongbin Han, Kai Zhu, Kejia Lee, Bo Liu, Fugen Zhou, Yu Fu, Qingyuan He,