Acute cocaine increases phosphorylation of CaMKII and GluA1 in the dorsolateral striatum of drug naïve rats, but not cocaine-experienced rats

► We modeled cocaine addiction and relapse via rodent drug self-administration and reinstatement. ► We measured changes in protein expression in subregions of the dorsal striatum with western blot. ► Acute cocaine increased phosphorylation of CaMKII and GluA1 in the dorsolateral striatum. ► Dorsolateral striatum phospho-CaMKII and -GluA1 is unchanged in cocaine-experienced rats.