کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6283640 | 1615164 | 2013 | 5 صفحه PDF | دانلود رایگان |
It is well known that spinal glia plays a key role in the pathogenesis of pain. The present study was designed to determine the roles of spinal microglia in bee venom-induced persistent spontaneous nociception (PSN), mechanical hyperalgesia and inflammation. We determined the effects of microglia inhibitor minocycline on BV-induced PSN, mechanical hyperalgesia and inflammatory swelling. Pre-treatment with intrathecal administration of minocyline at different doses significantly inhibited BV-induced PSN and mechanical hyperalgesia, but had no effect on BV-induced inflammatory swelling. These data suggest that the activation of spinal microglia may play a key role in BV-induced nociception, but not inflammation.
⺠Spinal microglia inhibitor inhibited bee venom-induced persistent spontaneous nociception and mechanical hyperalgesia. ⺠Spinal microglia inhibitor had no effect on bee venom-induced inflammatory edema. ⺠Spinal microglia may contribute to bee venom-induced nociception, but not inflammation.
Journal: Neuroscience Letters - Volume 534, 8 February 2013, Pages 301-305