Gabapentin and (S)-pregabalin decrease intracellular d-serine concentrations in PC-12 cells

► Gabapentin decreases intracellular d-serine, IC50 = 3.40 ± 0.29 μM. ► (S)-pregabalin decreases intracellular d-serine, IC50 = 3.38 ± 0.21 μM. ► Gabapentin and (S)-pregabalin do not affect serine racemase expression.