کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6283752 1296634 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Right lateralized white matter abnormalities in first-episode, drug-naive paranoid schizophrenia
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Right lateralized white matter abnormalities in first-episode, drug-naive paranoid schizophrenia
چکیده انگلیسی

Numerous studies in first-episode schizophrenia suggest the involvement of white matter (WM) abnormalities in multiple regions underlying the pathogenesis of this condition. However, there has never been a neuroimaging study in patients with first-episode, drug-naive paranoid schizophrenia by using tract-based spatial statistics (TBSS) method. Here, we used diffusion tensor imaging (DTI) with TBSS method to investigate the brain WM integrity in patients with first-episode, drug-naive paranoid schizophrenia. Twenty patients with first-episode, drug-naive paranoid schizophrenia and 26 healthy subjects matched with age, gender, and education level were scanned with DTI. An automated TBSS approach was employed to analyze the data. Voxel-wise statistics revealed that patients with paranoid schizophrenia had decreased fractional anisotropy (FA) values in the right superior longitudinal fasciculus (SLF) II, the right fornix, the right internal capsule, and the right external capsule compared to healthy subjects. Patients did not have increased FA values in any brain regions compared to healthy subjects. There was no correlation between the FA values in any brain regions and patient demographics and the severity of illness. Our findings suggest right-sided alterations of WM integrity in the WM tracts of cortical and subcortical regions may play an important role in the pathogenesis of paranoid schizophrenia.

► WM alterations in multiple regions may be involved in the pathogenesis of schizophrenia. ► Patients with first-episode, drug-naive paranoid schizophrenia were enrolled in the study. ► TBSS method could detect WM tracts integrity alterations in patients and controls. ► WM changes of cortical and subcortical areas attribute to pathogenesis of paranoid schizophrenia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 531, Issue 1, 30 November 2012, Pages 5-9
نویسندگان
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