The influence of DHEA pretreatment on prepulse inhibition and the HPA-axis stress response in rat offspring exposed prenatally to polyriboinosinic-polyribocytidylic-acid (PIC)

► PIC prenatal treatment leads to disrupted PPI in rat offspring. ► Disrupted PPI is reversed by DHEA pretreatment in females. ► DHEA pretreatment restores HPA axis stress response in PIC-treated rats. ► DHEA prenatal administration may demonstrate postnatal neurodevelopment effects.