Neurofilament protein levels: Quantitative analysis in essential tremor cerebellar cortex

► Studies have identified structural changes in the cerebellum in essential tremor. ► Among these changes is an increase in neurofilament-filled axonal swellings. ► We performed a quantitative Western blot analysis of postmortem cerebellar cortex. ► The phosphorylation state of neurofilament proteins differed in cases versus controls. ► These changes could be of mechanistic importance.