Nornicotine application on cockroach dorsal unpaired median neurons induces two distinct ionic currents: Implications of different nicotinic acetylcholine receptors

► Application of nornicotine induces two distinct ionic currents. ► Alpha-bungarotoxin induces a rapid desensitization of type 1 and blocks type 2 currents. ► Mecamylamine and d-tubocurarine block types 1 and 2 currents. ► Nornicotine acts as a partial agonist of DUM neuron nicotinic receptors.