Allicin ameliorates cognitive deficits ageing-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways

► The hippocampus neuron of the aged impaired mouse is under oxidative stress. ► Nrf2 levels appears to decline with aging. ► Allicin treatment significantly ameliorated ageing-induced cognitive dysfunction. ► Allicin treatment reduced oxidative damage in the hippocampus of aged mouse. ► Allicin treatment enhanced Nrf2 antioxidant signaling pathways.