Elucidating the role of 5-HT1A and 5-HT7 receptors on 8-OH-DPAT-induced behavioral recovery after experimental traumatic brain injury

► 8-OH-DPAT induces cognitive benefits after experimental TBI. ► 5-HT1A receptor antagonism does not abate the 8-OH-DPAT-induced cognitive benefits. ► 5-HT7 receptor antagonism attenuates the 8-OH-DPAT-induced cognitive benefits. ► The 8-OH-DPAT-induce cognitive benefits after TBI may be mediated more by 5-HT7 vs. 5-HT1A receptors. ► 8-OH-DPAT-induced hypothermia is blocked by 5-HT1A, but not 5-HT7, receptor antagonism.