Modulatory role of glutamic acid on the electrical activities of pain-related neurons in the hippocampal CA3 region

► The hippocampal CA3 region contains the pain-related neurons. ► Glu is involved in the modulation of nociceptive response in CA3 region. ► MK-801can block non-NMDA receptor, i.e. showing the analgesic effect. ► The hippocampal CA3 region is an important pain regulation center.