Brain-derived neurotrophic factor (BDNF) reverses the effects of rapid eye movement sleep deprivation (REMSD) on developmentally regulated, long-term potentiation (LTP) in visual cortex slices

► Intracortical infusion of BDNF reverses synaptic plasticity effects of adolescent REMS deprivation. ► REMS contributes to the effects of BDNF activation on closure of the critical period in visual cortex. ► Adolescent REMS deprivation affects the development of visual cortical inhibitory mechanisms.