Effects of clonidine on bilateral pain behaviors and inflammatory response in rats under the state of neuropathic pain

► Clonidine attenuated bilateral tactile and thermal hypersensitivity. ► Clonidine reduces bilateral mRNA expression of microglial and astrocytic markers. ► Clonidine inhibited bilateral expression of spinal cytokines. ► The effects of clonidine were prevented by yohimbine. ► The effects of clonidine were partially reversed by naloxone.