Protective effects of lycopene against amyloid β-induced neurotoxicity in cultured rat cortical neurons

► Lycopene protects cortical neurons against Aβ-induced neurotoxicity. ► Lycopene inhibited the Aβ-induced reactive oxygen species generation. ► Lycopene inhibited the Aβ-induced mitochondrial membrane potential alteration. ► Lycopene restored the levels of Bax, Bcl-2, and caspase-3 activity.