Counteracting roles of metabotropic glutamate receptor subtypes 1 and 5 in regulation of pain-related spatial and temporal synaptic plasticity in rat entorhinal-hippocampal pathways

► Enhancement of entorhinal-hippocampal synaptic transmission by pain. ► mGluR1-mediated tonic inhibition of entorhinal-hippocampal pathways. ► mGluR5-mediated facilitation of entorhinal-hippocampal pathways.