Macrophages-mediated neurotoxic effects of intra-nigral manganese administration are attenuated by minocycline

► Intranigral Mn reduces striatal TH-IS and increases macrophages number at SNpc. ► Systemic minocycline reduces the macrophages number and striatal TH-IS loss. ► Mn neurotoxicity can be mediated by macrophage infiltration.