Alteration of the sialylation pattern and memory deficits by injection of Aβ(25-35) into the hippocampus of rats

► The Aβ25-35 increase the expression of 9-O-acetylated sialic acid moieties in hippocampal cells. ► The Aβ(25-35) produce unbalanced regulation for the expression of specific sialyltransferases. ► The Aβ(25-35) injection into hippocampus produces the memory loss in rat. ► The sialylation changes could be responsible for the resistance to death caused by Aβ(25-35).