Effect of COMT genotype on aggressive behaviour in a community cohort of schizophrenic patients

► The Met/Met genotype of COMT may have an effect on aggressive behaviour in schizophrenia. ► Met/Met homozygous patients had the most aggressive behaviour compared to Val/Val homozygous subjects. ► The dose of antipsychotics was not associated with the frequency of aggressive episodes. ► Met/Met subjects tended to receive higher doses of medication.