Sustained acceleration of colonic transit following chronic homotypic stress in oxytocin knockout mice

► Acute stress significantly accelerated colonic transit in WT and OXT-KO mice. ► Accelerated colonic transit was attenuated in WT mice following chronic stress. ► The colonic transit was still accelerated in OXT-KO mice following chronic stress. ► CRF was upregulated in OXT-KO and downregulated in WT mice after chronic stress.