SOD1 overexpression improves features of the oligodendrocyte precursor response in vitro

► Overexpression of hSOD1 increases proliferation rate and oligodendrocyte precursor cells (OPCs) in vitro. ► SOD1 overexpression in OPCs accelerates the acquisition of a mature oligodendrocyte (OL) phenotype in vitro. ► Overexpression of hSOD1 in OPCs, but not mature OLs, rescues cells from oxidative stress-mediated death.