Apocynin administration does not improve behavioral and neuropathological deficits in a transgenic mouse model of Alzheimer's disease

► We administered the NOX inhibitor apocynin to Tg19959 mice. ► We found that it did not improve cognitive and neuropathological deficits. ► However, apocynin reduced carbonyl levels in the cerebral cortex. ► We conclude that at the dose given, apocynin was not neuroprotective.