The effect of systemic injection of cyclosporin A on the phosphorylation of the PKC substrates MARCKS and GAP43 in the rat hippocampus

► Systemic injection of cyclosporin A induces hyperactivity of rats. ► Cyclosporin A increases phosphorylation of GAP43 and MARCKS in rat hippocampus. ► Cyclosporin A activates PKC in rat hippocampus.