Cannabinoid CB1 receptor expression and affinity in the rat hippocampus following bilateral vestibular deafferentation

▶ Vestibular lesions adversely affect the hippocampus. ▶ Hippocampal cannabinoid receptors are involved in synaptic plasticity. ▶ We investigated changes in cannabinoid receptors after vestibular damage in rat. ▶ Cannabinoid receptor expression was significantly reduced in the CA3 area only. ▶ There was no significant change in cannabinoid receptor affinity.