کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6285122 | 1296738 | 2011 | 6 صفحه PDF | دانلود رایگان |

We immunohistochemically investigated the distribution of CXCL14, also called BRAK protein in the rat hypothalamus using anti-human CXCL14 serum. CXCL14-immunoreactive somata were localized in the periventricular area and paraventricular and supraoptic hypothalamic nuclei. In the former, immunoreactive neuronal somata, confirmed by double staining with a neuronal marker, NeuN, contained diffuse CXCL14-like immunoreactivity in their perikarya. In contrast, immunoreactive somata in the latter contained immunoreactive puncta within their perikarya. Very dense immunoreactive fibers and puncta were seen in the median eminence. Dense immunoreactive fibers were seen in the arcuate nucleus and ventromedial hypothalamic nucleus. Other hypothalamic areas contained a few immunoreactive fibers and puncta. These results demonstrated for the first time that CXCL14 protein is present in a subset of hypothalamic neurons and suggest that CXCL14 participates in hypothalamic functions such as control of autonomic nervous systems and/or participates in immune cell recruitment via the median eminence.
Research highlightsâ¶ A chemokine, CXCL14 is localized in hypothalamic neurons. â¶ CXCL14-containing fibers are accumulated in the median eminence. â¶ CXCL14 may act as a neuromodulator. CXCL14 may participate in immune cell recruitment via the median eminence.
Journal: Neuroscience Letters - Volume 487, Issue 3, 10 January 2011, Pages 335-340