کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6285899 1296960 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Response of risperidone treatment may be associated with polymorphisms of HTT gene in Chinese schizophrenia patients
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Response of risperidone treatment may be associated with polymorphisms of HTT gene in Chinese schizophrenia patients
چکیده انگلیسی
Serotonin transporter (5-HTT) is a key component of the serotonergic neurotransmitter system. Few studies have focused on polymorphisms of the serotonin transporter and antipsychotic response and, in particular, there have so far been no published studies on the association between the serotonin transporter and response to risperidone. This study examined the relationship between two polymorphisms of the serotonin transporter and the efficacy of risperidone treatment in 129 patients with schizophrenia. Our results revealed that patients with l allele of HTTRLP showed a greater improvement than those without l allele on the overall brief psychiatric rating scale (BPRS) (P = 0.025). But no such relationship was found for the HTTVNTR. In haplotype analysis, the frequency of L-12 haplotype showed a significant difference between the responder group and the non-responder group (P = 0.005). Our study has, for the first time, produced evidence that the potential for therapy in patients with schizophrenia is related to the HTTRLP polymorphism in the HTT gene and haplotype L-12 may help to predict risperidone treatment efficiency.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 414, Issue 1, 27 February 2007, Pages 1-4
نویسندگان
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