کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6286345 1615304 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Review articleMultifaceted neuro-regenerative activities of human dental pulp stem cells for functional recovery after spinal cord injury
ترجمه فارسی عنوان
بررسی اثر مولکولی فعالیت های نورولوژیک بازسازی سلول های بنیادی پالپ دندان انسان برای بهبود عملکرد پس از آسیب نخاعی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- We summarized a primary character of dental pulp stem cells.
- Pulp stem cells promote functional recovery after SCI of model animals.
- Pulp stem cells exert multifaceted neuro-regenerative activities.

Spinal cord injury (SCI) often leads to persistent functional deficits due to the loss of neurons and glia and to limited axonal regeneration after such injury. Recently, three independent groups have reported marked recovery of hindlimb locomotor function after the transplantation of human adult dental pulp stem cells (DPSCs) and stem cells from human exfoliated deciduous teeth (SHEDs) into rats or mice with acute, sub-acute or chronic SCI. This review summarizes the primary characteristics of human dental pulp stem cells and their therapeutic benefits for treating SCI. Experimental data from multiple preclinical studies suggest that pulp stem cells may promote functional recovery after SCI through multifaceted neuro-regenerative activities.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 78, January 2014, Pages 16-20
نویسندگان
, , , , ,