کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6287023 | 1615567 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Induction of single-sided deafness in the newborn rat and its consequence for cochlear nucleus volume development
ترجمه فارسی عنوان
القاء یک ناشنوایی یک طرفه در موش نوزاد و نتیجه آن برای توسعه حجم هسته کوهلر
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کلمات کلیدی
DCNSSDABRPVCNSingle sided deafnessCurrent levelVCNAVCNeABR - EABRThreshold - آستانهipsi - آنهاStapes - استاپسevoked potential - بالقوه را تحریک می کندEIS - تثبیت کننده الکترونیکی تصویر یا EISNormal hearing - جلسه عادیTympanic cavity - حفره تمپانکCochlea - حلزون گوشdecibel - دسیبلipsilateral - دو طرفهsensation level - سطح احساسFacial nerve - عصب صورتstapedius muscle - عضله استپدیوسcontra - علیهtympanic membrane - غشای تمپانAuditory brainstem - مغز گوش شنواییventral cochlear nucleus - هسته حلقوی شکمیCochlear Nucleus - هسته کچلرPosteroventral cochlear nucleus - هسته کچلر Posteroventraldorsal cochlear nucleus - هسته کچلی پشتیanteroventral cochlear nucleus - هسته کچلیون anteroventralauditory brainstem response - پاسخ شنوایی مغزround window - پنجره گردcontralateral - کنتراست
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های حسی
چکیده انگلیسی
Aim of this study was to induce a single-sided deafness (SSD) in rats before hearing onset. Rats were operated at postnatal day 10 by approaching the tympanic cavity along a retroauricular path without manipulating ossicles or tympanic membrane. The ototoxic aminoglycoside neomycin was injected intracochlearly through the round window membrane on one side. When the animals have reached young adult stages, their hearing threshold was determined by their auditory brainstem response (ABR). Monaural deafening was considered successful when the hearing threshold was at least 95Â dB above the threshold of the normal hearing ear. Growing up with one non-functional ear, rats developed a striking anatomical asymmetry of their cochlear nuclei (CN). The CN from age-matched normal hearing brains and from both sides of single-sided deaf brains were cut into series of frontal sections and their volumes calculated. No difference was detected between the volume of the normal hearing CN and the contralateral CN in SSD rats. By contrast, growth retardation was found for the ventral CN on the deaf side to result in a volume of only 57% compared to the normal hearing side. Marginal growth retardation was also observed for the dorsal CN on the deaf side. Thus, loss of sensory activation leads mainly, but not exclusively, to a reduction of tissue volume in the ventral CN of the deaf side, leaving the contralateral side apparently unaffected.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 333, March 2016, Pages 210-215
Journal: Hearing Research - Volume 333, March 2016, Pages 210-215
نویسندگان
Till F. Jakob, Nicole Rosskothen-Kuhl, Robert-Benjamin Illing,