کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6287167 | 1615568 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Partial corrosion casting to assess cochlear vasculature in mouse models of presbycusis and CMV infection
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های حسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Partial corrosion casting to assess cochlear vasculature in mouse models of presbycusis and CMV infection Partial corrosion casting to assess cochlear vasculature in mouse models of presbycusis and CMV infection](/preview/png/6287167.png)
چکیده انگلیسی
Some forms of sensorineural hearing loss involve damage or degenerative changes to the stria vascularis and/or other vascular structures in the cochlea. In animal models, many methods for anatomical assessment of cochlear vasculature exist, each with advantages and limitations. One methodology, corrosion casting, has proved useful in some species, however in the mouse model this technique is difficult to achieve because digestion of non vascular tissue results in collapse of the delicate cast specimen. We have developed a partial corrosion cast method that allows visualization of vasculature along much of the cochlear length but maintains some structural integrity of the specimen. We provide a detailed step-by-step description of this novel technique. We give some illustrative examples of the use of the method in mouse models of presbycusis and cytomegalovirus (CMV) infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 332, February 2016, Pages 95-103
Journal: Hearing Research - Volume 332, February 2016, Pages 95-103
نویسندگان
Mattia Carraro, Albert H. Park, Robert V. Harrison,