کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6287441 | 1615591 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression patterns of atrial natriuretic peptide and its receptors within the cochlear spiral ganglion of the postnatal rat
ترجمه فارسی عنوان
الگوهای بیان پپتید پروتئین نای توریستی و گیرنده های آن در داخل گانگلیون مارپیچی کچل موش پس از تولد
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کلمات کلیدی
ANPSGNsnatriuretic peptide receptor-CNPR-Cnatriuretic peptide receptor-ANPR-ASGCsRT-PCRcGMPcAMP - cAMPCyclic adenosine monophosphate - آدنوزین مونوفسفات CyclicCNS - دستگاه عصبی مرکزیsatellite glial cells - سلول های گلیال ماهواره ایcentral nervous system - سیستم عصبی مرکزیcyclic guanosine monophosphate - مونوفسفات گوانوزین چرخه ایSpiral ganglion neurons - نورونهای گانگلیونی اسپیرالreverse transcription-polymerase chain reaction - واکنش زنجیره ای رونویسی-پلیمراز معکوسatrial natriuretic peptide - پپتید نایروئیدوری دهلیزguanylyl cyclase - گویینیل سیکلاس
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های حسی
چکیده انگلیسی
The spiral ganglion, which is primarily composed of spiral ganglion neurons and satellite glial cells, transmits auditory information from sensory hair cells to the central nervous system. Atrial natriuretic peptide (ANP), acting through specific receptors, is a regulatory peptide required for a variety of cardiac, neuronal and glial functions. Although previous studies have provided direct evidence for the presence of ANP and its functional receptors (NPR-A and NPR-C) in the inner ear, their presence within the cochlear spiral ganglion and their regulatory roles during auditory neurotransmission and development is not known. Here we investigated the expression patterns and levels of ANP and its receptors within the cochlear spiral ganglion of the postnatal rat using immunofluorescence and immunoelectron microscopy techniques, reverse transcription-polymerase chain reaction and Western blot analysis. We have demonstrated that ANP and its receptors colocalize in both subtypes of spiral ganglion neurons and in perineuronal satellite glial cells. Furthermore, we have analyzed differential expression levels associated with both mRNA and protein of ANP and its receptors within the rat spiral ganglion during postnatal development. Collectively, our research provides direct evidence for the presence and synthesis of ANP and its receptors in both neuronal and non-neuronal cells within the cochlear spiral ganglion, suggesting possible roles for ANP in modulating neuronal and glial functions, as well as neuron-satellite glial cell communication, within the spiral ganglion during auditory neurotransmission and development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 309, March 2014, Pages 103-112
Journal: Hearing Research - Volume 309, March 2014, Pages 103-112
نویسندگان
Fei Sun, Ke Zhou, Shu-juan Wang, Peng-fei Liang, Miao-zhang Zhu, Jian-hua Qiu,