Spiral ganglion cell morphology in guinea pigs after deafening and neurotrophic treatment

► After deafening spiral ganglion cells become smaller within one week, before they die. ► After BDNF treatment cells become larger, also where cell survival is not enhanced. ► Morphological changes are not restricted to a subpopulation of spiral ganglion cells. ► Cell size changes and cell death may be manifestations of separate mechanisms. ► Size, circularity and intracellular density may be indicative of the cell's stability.