Experimental study of the relationship between Plasmodium gametocyte density and infection success in mosquitoes; implications for the evaluation of malaria transmission-reducing interventions

- Infection outcome in mosquito increases with Plasmodium falciparum gametocyte density.
- At high Plasmodium berghei gametocyte densities, infection outcome in mosquito decreases.
- Reduction of infection intensity by mAb 13.1 was constant over oocyst intensities.
- Reduction of infection prevalence by mAb 13.1 decreases at high infection loads.
- Evaluation of TRIs should report reduction of infection intensity and prevalence.