In silico and in vitro comparative activity of novel experimental derivatives against Leishmania major and Leishmania infantum promastigotes

- We homologically modeled the PTR1 of nine different leishmania and protozoans.
- PTR1 of leishmania significantly differs from the other protozoan.
- New experimental derivatives could be a potential antileishmanial agent.
- Combinatorial in vitro with in silico may serve as a noble tools in drug designing.