Neolignan Licarin A presents effect against Leishmania (Leishmania) major associated with immunomodulation in vitro

- Licarin A inhibits the proliferation of Leishmania (L.) major promastigotesin vitro.
- This neolignan induces DNA fragmentation on L. (L.) major promastigotes.
- Licarin A is more effective against L. (L.) major intracellular amastigotes.
- Decrease in IL-6 and IL-10 cytokines levels suggest immunomodulation by licarin A.