Identification of calcium-transporting ATPases of Entamoeba histolytica and cellular localization of the putative SERCA

- Entamoeba histolytica contains five genes encoding putative Ca2+-ATPases.
- Three of the Ca2+-ATPases are grouped with plasma membrane elements (PMCA) and two with organellar members (SERCA and SPCA).
- All Ca2+-ATPases are expressed in E. histolytica trophozoites.
- The putative EhSERCA contains several of the structural domains of the rabbit SERCA1a.
- The putative EhSERCA is located in a continuous cytoplasmic network and co-localized with calreticulin.