Leishmanicidal activity of an alkenylphenol from Piper malacophyllum is related to plasma membrane disruption

► Alkenylphenol gibbilimbol B was isolated from Piper malacophyllum. ► Gibbilimbol B was evaluated in vitro against Leishmania spp. and Trypanosoma cruzi. ► L. (L.) infantum chagasi and T. trypomastigotes were susceptible to gibbilimbol B. ► The alkenylphenol suggested the disruption of the Leishmania plasma membrane at initial incubation time.