Effects of IFN-γ, TNF-α, IL-10 and TGF-β on Neospora caninum infection in rat glial cells

► Rat glial cultures (IFN-γ, TNF, anti-IL-10 or anti-TGF-β treated) were infected with Neospora caninum. ► Inflammatory cytokine and regulatory cytokine depletion reduce parasite proliferation. ► Parasite infection downmodulated NO production and it was more expressive in IFN-γ/infected cells. ► IFN-γ triggers some mechanisms of parasite evasion in infected glia cell.