Different susceptibilities of Leishmania spp. promastigotes to the Annona muricata acetogenins annonacinone and corossolone, and the Platymiscium floribundum coumarin scoparone

► Acetogenins were isolated from A. muricata and scoparone from P. floribundum. ► All compounds inhibited the promastigote growth in the three species. ► Annonacinone presented high leishmanicidal activity. ► Corossolone, and scoparone demonstrated moderate leishmanicidal actions. ► Toxicity was tested using A. salina assay, corossolone was the most toxic compound.