Nitric oxide level, protein oxidation and antioxidant enzymes in rats infected by Trypanosoma evansi

► Trypanosoma evansi is the causative agent of an important disease that affects a wide variety of domestic and wild mammals. ► Nitric oxide has many physiological effects in body animals and human. ► NO level in serum, indicated by nitrite/nitrate concentration, was higher in infected rats with T. evansi. ► Serum AOPP level was higher in infected rats by parasite, i.e. protein oxidation. ► An increase in antioxidant enzyme activity occur in infection by T. evansi caused by oxidative damage.