Trypanosoma cruzi: Effects of azadirachtin and ecdysone on the dynamic development in Rhodnius prolixus larvae

► PTTH triggers edysone synthesis from prothoracic glands. ► Into midgut, ecdysone induces differentiation of Trypanosoma cruzi round form to epimastigote. ► In the rectum, epimastigotes can then develop to metacyclic trypomastigotes.