Characterization of Schistosoma japonicum estrogen-related receptor beta like 1 and immunogenicity analysis of the recombinant protein

► The expression of SjEsRRBL1 was higher in worms from mice than from Microtus fortis. ► The expression of SjEsRRBL1 was higher in worms from female than from male mice. ► The rSjEsRRBL1 induced partial protective efficacy in two independent trials. ► The concentration of serum IFN-γ and IL-4 from mice immunized with rSjEsRRBL1 increased.