ABC transporters influence sensitivity of Brugia malayi to moxidectin and have potential roles in drug resistance

► ABC systems impact heath and illness by mediating multidrug resistance (MDR) via overexpression. ► ABC systems that confer MDR are found in subfamilies A, B, C, and G; in nematodes they are in subfamily B. ► Following moxidectin treatment there was overexpression of ABC systems in subfamilies A, B, C, and G. ► Inhibition of ABC systems potentiated sensitivity of females and microfilariae to moxidectin. ► ABC systems in Brugia malayi influence sensitivity to moxidectin and may affect drug resistance.