Leishmania amazonensis: Effects of oral treatment with copaiba oil in mice

► Copaiba oil oral treatment caused a significant reduction in the lesion size in mice. ► We demonstrated that copaiba oil not showed toxicity and genotoxicity. ► Parasite cells had morphological and ultrastructural changes. ► We showed alterations in plasma membrane permeability of parasite. ► Depolarization in the mitochondrial membrane potential after copaiba oil treatment.