Calcium signal regulates temperature-dependent transformation of sporozoites in malaria parasite development

► The infection by the malaria parasite is initiated in host hepatocyte. ► The intracellular calcium increased during sporozoite transformation. ► Modulators of calcium signaling accelerated the sporozoite-rounding process. ► Calcium signal regulates the morphological development of sporozoite to EEF. ► We proposed a role for calcium as a transducer in the parasitic life cycle.