Optimization of endochin-like quinolones for antimalarial activity

► Synthesis of endochin analogs with enhanced antiparasitic activity. ► Identification of endochin analogs that are equipotent against multidrug-resistant parasites. ► Identification of endochin analogs that are equipotent against atovaquone resistant parasites. ► Prodrug of endochin analog ELQ-121 cures murine malaria by oral route.