کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6292031 | 1302511 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Giardia lamblia: Interleukin 6 and tumor necrosis factor-alpha release from mast cells induced through an Ig-independent pathway
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
انگل شناسی
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![عکس صفحه اول مقاله: Giardia lamblia: Interleukin 6 and tumor necrosis factor-alpha release from mast cells induced through an Ig-independent pathway Giardia lamblia: Interleukin 6 and tumor necrosis factor-alpha release from mast cells induced through an Ig-independent pathway](/preview/png/6292031.png)
چکیده انگلیسی
Giardia lamblia is a common cause of both acute and chronic diarrheal disease in humans worldwide. It has been shown that mast cells, IL-6 and TNF-α are substantially involved in the early control of G. lamblia infection in mice. However, no studies have yet been reported concerning the interaction between mast cell and Giardia, as well as the mast cells mediators generated in response to Giardia infection. In this study we demonstrated the direct activation of mast cells by G. lamblia live trophozoites or trophozoite-derived antigens followed by an increase in tryptase expression and a significant release of the preformed mediator histamine. In addition, parasite derived antigens increased TNF-α and de novo synthesized cytokine IL-6, at the mRNA and protein level. These results strongly suggest that mast cells might be an important source not only of IL-6 but also of TNF-α during Giardia infection, playing an important role in the outcome of the infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Parasitology - Volume 126, Issue 3, November 2010, Pages 298-303
Journal: Experimental Parasitology - Volume 126, Issue 3, November 2010, Pages 298-303
نویسندگان
Samira Muñoz-Cruz, Argelia Gómez-GarcÃa, Jarenny Millán-Ibarra, Silvia Giono-Cerezo, Lilián Yépez-Mulia,