Cytokines in rats experimentally infected with Trypanosoma evansi

► Trypanosoma evansi is transmitted to the host and multiplies in the skin or mucosa. ► Stimulates the production of B cells and T cells. ► Progressively increases IFN-γ following the evolution of infection. ► Activates the macrophages and induces pro-inflammatory cytokines TNF, IL-1 and IL-6. ► Anemia development and immune response in rats infected with T. evansi.